Antibody reagent kit RM17606

solutionELISA testprotein

The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It''''s been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate. Immunogen - HK293 derived SARS-COV-2 S1+S2 ECD(S-ECD) Purirty - Affinity purification Ig Type - Rabbit IgG Endotoxin Level - < 1.0 EU/μg of the protein by LAL method. Formulation - Supplied as a 0.2um filtered solution in PBS with 0.1%Braveds MB-1, PH 7.4. CrossReactivity - Has cross-reactivity in ELISA with SARS-CoV-2 Spike S1 Protein (Cat# RP01262) SARS-CoV-2 S1+S2 ECD(S-ECD) Protein (Cat# RP01284) No cross-reactivity in ELISA with MERS-CoV Spike S1 Protein