HHV-6 assay kit MOLgen

rubellaherpeslipid

"MOLgen DNA HHV-6 S1 Kit" is an assay kit for the detection of Human herpes virus (HHV) type 6 DNA by real-time PCR method. Introduction Pathogen information: Herpesvirus-6 (HHV-6) is a member of the Herpesviridae family. These viruses contain DNA surrounded by a lipid envelope. HHV-6 exists as 2 closely related variants, HHV-6 A and HHV-6 B. HHV-6 transmission occurs most frequently through the shedding of viral particles into saliva. The salivary glands are regarded as an in vivo reservoir for HHV-6. The virus infects the salivary glands, establishes latency, and periodically reactivates to spread infection to other hosts [1]. The cases of vertical transmission has also been described. The infection may occur parenterally, i.e. during transplantations or blood transfusions. Following the primary infection (which mainly occurs early in childhood), the virus establishes a latent infection in lymphocytes and monocytes and may persist in various tissues (blood, brain, liver, salivary glands, lungs, heart tissue, endothelium) with a low level of replication [2]. Mostadults (80%-90%) havebeeninfectedwiththisvirus.Primary infections in adults are rare. The majority of HHV-6 infections are asymptomatic. The manifestations in immunocompetent people include fever that may exceed 400C (persisting for 3-4 days) and exanthem subitum (roseola infantum), resembling measles or rubella symptoms. In immunocompromised patients, primary infection or reactivation may lead to serious complications. Clinical symptoms associated with primary or reactivated HHV-6 in adults may involve febrile illness, pneumonitis, chronic or fulminant hepatitis, meningoencephalitis, meningitis,