More than 1,000 mutations in the CFTR gene have been associated with cystic fibrosis. Most of these mutations in the CFTR gene change the production, structure, or stability of the chloride channel. All of these charevent the channel from functioning properly, which impairs the transport of chloride ions and the movement of water into and out of cells, resulting in cells lining the passageways of the lungs, pancreas, and other organs producing abnormally thick and sticky mucus. The abnormal mucus blocks the airways and glands, leading to the complications of respiratory, digestive and reproductive systems.
Product details:
The assay is an in vitro PCR reaction assay for the Qualitative determination of Cystic Fibrosis (CFTR) in the human sample such as Human Whole Blood and based on Taqman detection method for Cystic Fibrosis (CFTR) with high sensitive one step qPCR kit.
The Zena Max Cystic Fibrosis (CFTR) PCR kit is very sensitive and up to 100% specific for the 8 most common Cystic Fibrosis (CFTR) mutations under our validation methods and devices.