Protein analysis reagent 52009005

blood samplefor nephelometrycystatin C

Intended Use This reagent is intended for in vitro quantitative determination of Cystatin-C in human serum. -Nephelometry methodology -Ready to use reagents -No sample dilution required -Linear upto 10 mg/L -No calibration required Clinical Significance Cystatin C is a low molecular weight (13 Da) cytoplasmic protein, functioning as an inhibitor of various cystein protease in the blood stream. Cystatin-C has a stable production rate and is removed from the blood circulation by glomerular filtration. In healthy individuals Cystatin-C is completely reabsorbed and degraded in the tubules but in subjects with renal disorders its level in blood may be raised as high as 2 to 5 times the normal values. Cystatin-C is superior to serum creatinine as a marker of glomerular filtration Rate (GFR). Principle Cystatin C in the test sample binds to the specific polyclonal rabbit anti-Cystatin C antibody, which has been adsorbed to latex particle and agglutinates. The agglutination is directly proportional to the quantity of Cystatin C in the sample