Research test kit 17-HISHU-E01

allergyfor histamineblood

The Histamine ELISA is intended for the quantitative determination of Histamine in plasma and urine. - Contains two ready-to-use controls - Wide standard ranges, convenient measurement of pathological samples without predilution. For Research Use Only. Not for Use in Diagnostic Procedures. Regulatory Status Research Use Only. Not for Use in Diagnostic Procedures. Product Distribution Available Worldwide Range 0.3 - 30 ng/mL Sensitivity See Package Insert Sizes 96 Wells Inc Time Overnight No Inc Time See Protocol No Sample Size 25 Additional Information Histamine belongs to the biogenic amines and is synthesized by decarboxylation from the amino acid histidine. It is synthesized by mast cells, basophils, platelets, histaminergic neurons, and enterochromaffin cells, where it is stored intracellularly in vesicles and released on stimulation. Histamine acts by binding to its 4 receptors (H1R, H2R, H3R, and H4R) on target cells in various tissues. It causes smooth muscle cell contraction, vasodilation, increased vascular permeability and mucus secretion, tachycardia, alterations of blood pressure, and arrhythmias. Research demonstrates that in humans, histamine is one of the most important mediators and takes part in the initial phase of an anaphylactic reaction (“immediate type” allergy).