Vial for the pharmaceutical industry AT-CryoBox™

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Since 2002 at Aseptic Technologies we explore ways to make aseptic fill & finish process safer and easier, responding to new challenges of biopharmaceutical injectable developers and their CDMOs. We fundamentally re-invented the entire process of fill & finish starting with its core element: the vial or more precisely the entire container closure system. The AT-Closed Vial® and the AT-Closed Vial® Technology Filling Lines are a result of that reflection. The AT-Closed Vial® is a vial that is closed before filling. The vial body and stopper are assembled together right after molding, in ISO 5 conditions. The vials are therefore closed before the start of the fill & finish process, eliminating contamination risks. Its unique material composition and manufacturing technique also enables the AT-Closed Vial® to secure Container Closure Integrity (CCI) during cryopreservation. De-risking aseptic filling Unique ready-to-fill polymer vials (COC) Vial bodies and stoppers molded and assembled in ISO5 Ranging from < 1 ml to 50 ml Closed throughout the filling process, eliminating contamination risks by design The closed vial filling is performed in 3 steps with dedicated filling equipment in ISO 5 : The vial is filled through the stopper with a special sterile needle. After the piercing, the stopper mechanically recloses thanks to its elasticity The stopper is re-sealed with a one-second laser shot The sterile snap-fit cap is placed on the vial to protect the stopper until the collection of the product Cryopreservation The AT-Closed Vial® technology enables safe cryogenic storage of the injectable drug product and its intermediate GMP-grade products.