As one of the most important endocrine organs in the human body. The thyroid gland is mainly composed of thyroid follicles, Thyroid gland have the function of synthesizing, storing and secreting thyroid hormones. Thyroid hormone-triiodothyronine(T3) and Thyroxine(T4) are important regulatory hormones in the human body, which can promote the metabolism of the body, maintain the normal growth and development of the body, and also have an important influence on the development of bone and nervous system[1,2].
Since drugs and diseases may result in abnormality of total thyroid hormones, but free thyroid hormones (FT3 and FT4) are maintained at normal levels, so the detection of FT3 and FT4 has important clinical significance[3].
Thyroid-stimulating hormone (TSH) secreted by the pituitary gland participates in the regulation of the hypothalamus-pituitary-thyroid axis, so as to achieve the dynamic balance of thyroid hormones in the body[4].
Autoimmune Thyroid Disease is caused by disorders of the patient's Autoimmune system, mainly including Hashimoto's thyroiditis and Graves' Disease, etc., and the formation of these thyroid diseases is closely related to thyroglobulin (TG) and Thyroid peroxidase (TPO)[5].
Clinical Significance
Accurate determination of TSH is the first choice to judge whether the thyroid and hypothalamic-pituitary-thyroid axis function is normal.
T3 test can effectively assess thyroid function:(1) diagnosis and early diagnosis of hyperthyroidism;(2) To evaluate the therapeutic effect of hyperthyroidism;(3) Diagnosis of hypothyroidism, course observation and curative effect diagnosis.[6]