Anemia is a common clinical symptom that the volume of peripheral red blood cells decreases and is lower than the lower limit of the normal range. The earliest symptoms of anemia include dizziness, fatigue and drowsiness, whereas the most common and noticeable physical sign is facial paleness. The severity of these symptoms depends on the rate and intensity of anemia as well as the body's compensatory capacity. Anemia affects the function of the nervous, digestive and also respiratory systems.
Clinical Significance
Folate is a type of water soluble vitamin. After being absorbed by the human body, folate exists in the tissues of intestinal wall, liver and bone marrow, etc. It can be reduced by folate reductase - a process that also requires NADPH - into its bioactive form, tetrahydrofolic acid, which then participates in the synthesis of purines and pyrimidine. Therefore, folate is important to protein synthesis, and also plays a critical role in the process of cell division and growth. In addition, folate facilitates the development of healthy red blood cells. A lack of folate could induce the reduction of hemoglobin production in red blood cells and inhibit cell maturation, which in turn results in megaloblastic anemia, particularly in pregnant women and infants.
Vitamin B12 is also named cobalamin, which is a water soluble vitamin that participates in the metabolic activities of all human cells. The primary food source of Vitamin B12 is meat, while among plants, it is also contained by soybeans and certain herbs.Vitamin B12 can be synthesized by gut microbiota, and thus normally would not be deficient in the human body. However,