Oncology test kit

for genotypingfor animalsgenetic

Optical genome mapping (OGM) requires labeled ultra-high molecular weight (UHMW) DNA for identification of structural variants. Bionano provides a suite of DNA sample prep kits for simple and robust isolation of UHMW DNA from a range of important sample types. Once DNA has been isolated, our Direct Label and Stain (DLS) kits can be used to label DNA for use with the Saphyr system. Achieve robust isolation and labeling of UHMW DNA. The ability to visualize large genomic structural variants requires exceptionally large intact fragments of DNA. The Bionano solution phase (SP) technology allows for the isolation of DNA fragments that can achieve >1 Mbp in length and routinely yields average fragments of >230 kbp. Putting this in perspective, short read sequencing produces reads of up to 150 bp while leading high accuracy long-read sequencing provides read lengths up to 25kb. Isolate DNA from a range of important sample types. The latest Bionano SP DNA prep kits are capable of purifying UHMW DNA from tissue and tumor, bone marrow aspirate (BMA), blood and cells as well as plant and animal tissue. This sample diversity makes OGM suitable for use in a broad range of studies and applications in oncology, constitutional genetic disease, bioprocessing and general research. Bionano’s SP kits require 1.5 * 10^6 cells (blood, cell lines and BMA) or 10 – 30 mg of tissue as input. UHMW DNA is isolated in about four hours using a lyse, bind, and wash process, and novel paramagnetic disks.