Animal research Vogel test LE865

for micefor ratsfor drug development

Conflict test that has become a standard for fast screening the potential anxiolytic properties of drugs Many different animal models have been developed for testing the effects of anti-anxiety drugs on behaviour. The most frequently behavioural action is the anxiolytic ability to increase response rates suppressed by delivery of response-dependant punishment. One of the most popular versions of this technical approach is that developed by R.A. Vogel in 1971 (Psychopharm. (Berl.), 21:1-7). In this model, licking of drinking tube suppression in water-deprived rats, is reestablished by anxiolytic pretreatment. As the model can be used with naive rats in one test session, it has become a standard for fast screening of anxiolytic activity of drugs. Operating principle Our instrument is a fully automated set up fulfilling all the control needs of the Vogel's Test, and allowing test performance in a single and easy to use experimental unit. The set-up is formed by the animal cage, and a modular control unit that include a shock generator. The animal cage The animal cage is made up of black perspex with an upper access door and an electrificable grid floor (stainless steel bars, 4 mm dia., spaced 10 mm); frontal panel & upper door are made of transparent perspex. The drinking tube is installed in one of the box sides; it is provided with a resistive detector for animal approaches to water and allows measuring of water consumption and water loss.