Ion mobility spectrometer timsTOF MALDI PharmaPulse®

masssynthesisMALDI-TOF

New insights into molecular interactions by label-free HTS taking advantage of innovative timsTOF technology. Taking label-free high-throughput screening to the next level Speed & Robustness timsTOF MALDI PharmaPulse® offers true uHTS capability with fast reading rates up to 3 wells / sec and proven MALDI robustness. TIMS enabled timsTOF MPP adds a new dimension to HTS by utilizing, for the first time ever, Trapped Ion Mobility Spectrometry for ultrafast separation and CCS awareness. Specificity Superior HTS results provided by combining TIMS separation of isobars and isomers with sensitive readout by high-resolution accurate-mass QTOF-MS. Versatility Unmatched performance in a wide range of high-throughput applications ranging from quantitative assays to near real-time synthesis screening in HTE chemistry. Unbiased, deep HTS by label-free mass spectrometry The timsTOF MPP represents the flagship member of the Bruker PharmaPulse® product line. It features the extreme speed and proven robustness of MALDI and, for the first time ever in HTS, takes advantage of Bruker's innovative Trapped Ion Mobility Spectrometry (TIMS) technology. TIMS enables rapid gas-phase separation of isobars, and even isomers, by exploiting the molecular collisional cross-section. This, in combination with routine 50,000 mass resolution in QTOF-MS detection enables revolutionary levels of assay specificity at HTS speed. timsTOF MPP uses a dual MALDI / ESI ion source with industry-leading 10 kHz smartbeam™ 3D laser to enable uHTS compatible speed and throughput, and is available with the unique MALDI-2 option for an expanded chemical space.