Mass spectrometer timsTOF Pro 2

IMSfor research

The timsTOF Pro 2, powered by the latest parallel accumulation serial fragmentation (PASEF®) technology, paves the way for 4D-Multiomics applications. With its proven robustness, high sensitivity and fast MS/MS acquisition, timsTOF Pro 2 is the platform of choice for 4D-Proteomics™, 4D-Metabolomics™ and 4D-Lipidomics™. Speed PASEF® technology achieves a >120 Hz sequencing speed without affecting resolution. Depth Additional ion mobility dimension increases data completeness. Robustness The unique instrument design enables robust performance and routine operation over thousands of samples without requiring cleaning. The new standard for high speed, high sensitivity 4D-Multiomics Liquid chromatography (LC) coupled with mass spectrometry (MS) has become the gold standard in various omics fields. However, the coverage of proteomes or metabolomes in complex biological samples remains challenging due to limited speed, sensitivity and resolution of current mass spectrometers. Adding trapped ion mobility spectrometry (TIMS) to the equation unlocks the parallel accumulation serial fragmentation (PASEF®) acquisition method to provide extremely high MS/MS speed and sensitivity, requiring minimal sample amounts. Dual-TIMS and CCS-enabled analysis TIMS is first and foremost a separation technique in the gas phase. This resolves sample complexity through an added dimension of separation in addition to high performance liquid chromatography (HPLC) and mass spectrometry, increasing peak capacity and confidence in compound characterization. Equally important, the TIMS device also accumulates and concentrates ions of a given m/z and mobility,