1.ROS1 gene is expressed in brain, lung, gastric, breast and liver tumors, and translocated with other genes in non-small cell lung cancer cells (for example, SCL34A2, CD74, etc.).
2. The proportion of NSCLC patients with ROS1 translocation is about 3%. The drug of crizotinib can inhibit the growth of ROS1 fusion gene cells, and the detection of ROS1 gene breakapart can guide the administration of crizotinib.