1.MDM2 gene amplification can be used to assist in the differential diagnosis between well-differentiated liposarcoma and lipoma, help diagnose dedifferentiated liposarcoma, and well-differentiated osteosarcoma and benign or reactive bone lesions.
2.The gene amplification also occurred in osteosarcoma (16%) and esophageal cancer (13%).
3.Used to guide the treatment of MDM2 inhibitors.