S100p is a member of S100 family. This protein is widely distributed in normal tissues including heart, brain, liver, lung, bone marrow, peripheral blood leukocytes, etc., and expressed in cytoplasm and nucleus. Abnormal expression in tumors will play an important role in tumor growth, proliferation and nuclear metastasis through various signaling pathways.
Clinical Application
It is mainly used as a specific marker for the differential diagnosis of bladder cancer.
In bile duct biopsy specimens, S100p can help us distinguish cancer from reactive epithelial changes.