The approximate 50% of prostate cancers has fusion mutations, and TMPRSS2 ERG is the most common fusion gene. It is closely related to the aggressiveness and prognosis of prostate cancer. The EGR positive patients tend to have a higher stage of prostate cancer, a higher rate of recurrence, and a higher rate of pelvic lymph node metastasis.
Staining Tissue
As Figure shows:
Esophagus tissue stained with ERG