MSH6 is an important member of the mismatch repair family and is positioned on chromosome 2 P arm 16 point. The DNA length is 23806BP, while the main function is to correct base pair mismatch and small fragment insertion and deficiency. When DNA is mismatched, MSH6 protein and MSH2 protein combine to produce A MutS-α heterodimer that can be identified for the mismatch site. This The heterodimer is combined with the mismatch site and initiates the mismatch repair process, thus ensuring the stability of the microsatellite.
Staining Tissue
As Figure shows:
Colon adenocarcinoma tissue stained with MSH6