Thyroglobulin is a 670kD glycoprotein synthesized from follicles of the thyroid. This protein is expressed in normal thyroid follicular epithelium and glial, thyroid follicular adenoma, thyroid follicular carcinoma and papillary carcinoma. But cancers with poor differentiation from thyroid follicular epithelium such as undifferentiated cancer and anaplastic cancer, the expression of TG shows weak or negative.
Staining Tissue
As Figure shows:
Thyroid tissue stained with Tg