A diagnostic tool with dual Hyaluronan coated chambers for sperm sample evaluation
The HBA™ Assay is a diagnostic tool with dual hyaluronan coated chambers for sperm sample analysis. It allows the ability to distinguish between mature spermatozoa expressing hyaluronan receptors on their plasma membrane, and immature ones lacking those receptors.
The presence of receptors and the ability of spermatozoa to bind to hyaluronan is correlated with sperm maturity, increased chromatin integrity, decreased chances of aneuploidy, lower sperm DNA fragmentation and better sperm DNA packaging.1,2,3
The proportion of motile spermatozoa capable to bind to hyaluronan is called the Hyaluronan Binding index or HBA index. There is a correlation between the HBA index and ICSI treatment outcomes.4,5,6
Assessing the proportion of mature spermatozoa with hyaluronan receptors can be used to determine the best treatment options for the patients.
Easy to implement, simple to perform
Sperm sample evaluation takes minutes
More data on sperm quality for the informed choice of treatment tactics