Skin TEWL analysis system Invitro Tewameter® VT 310

Probe perfectly suited for TEWL-measurements on Franz cells With the Invitro Tewameter® VT 310 a probe for the TEWL measurement is available, which offers all benefits of the Tewameter® and is perfectly suited to sit on a Franz cell. The probe Tewameter® VT 310 emulates completely the upper part (donor chamber) of a Franz cell (standard is 15 mm Ø, other sizes on request). Thus the probes sits exactly on the membrane of the Franz cell as it would sit on skin directly without needing further adapters. The measured TEWL-value is expressed in g/h/m², the worldwide acknowledged absolute measuring value for skin. No other probe offers this possibility. VT with centerpiece If needed, the probe can also be used on a centerpiece of high quality Teflon, which fits exactly on the probe and the receptor chamber of the Franz cell without further fixing adapters. The thus measured TEWL has to be regarded relatively (no longer absolute figures as the distance between probe and membrane is changed). In vitro TEWL measurements have a variety of different applications: Inexpensive pre-screening before in vivo tests (no ethic commission, no expensive volunteers) Only way to study skin permeability and dermal absorption necessary for safety and efficacy testing In vitro tests and procedures to minimize the use of animals in tests are established in several worldwide acknowledged guidelines: e.g. ECVAM (European Centre for the Validation of Alternatives to Animal Testing), OECD (Organisation for Economic Co-operation and Development) or REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals)