TransFix stabilised blood is compatible with a range of methods for the isolation and analysis of circulating tumour cells (CTC). The number of CTC populations present in patient blood is very low, therefore the usefulness of CTC assessments depends upon accurate cell counts and the corresponding analysis of molecular targets.
Circulating Tumour Cell TransFix/EDTA Vacuum Blood Collection Tubes (CTC-TVTs) are 9ml evacuated tubes prefilled with TransFix. CTC-TVTs are specifically designed for the optimal collection and stabilisation of CTCs in whole human blood. They allow stabilisation of CTCs for up to 5 days immediately preventing the degradation of CTCs and CTC antigens, allowing time to isolate and analyse these rare cells.
CTC Tubes are for Research Use Only.
Benefits of CTC-TVTs
Easy to use – just collect blood and mix by inversion
Improved cell stability facilitating recovery of rare cells
Immediate Stabilisation at the time point of venepuncture
Published examples show compatibility with a range of CTC isolation and analysis techniques:
Size exclusion filtration and by cellular surface markers
Microscopic analysis and enumeration of CTCs in metastatic breast and lung cancer patients
Analysis of CTCs through high-resolution image flow cytometry
Cell sorting and mutation analysis
mRNA extraction