Compact and robust yet versatile system used for reactivity studies of isolated tissue such as smooth, skeletal and cardiac muscle.
The DMT Organ Bath is a comprehensive system used for contractile studies of isolated smooth, skeletal, or cardiac tissue. In a controlled environment, tissue segments are kept in a heated and oxygenated perfusate to maintain tissue viability, and contraction and relaxation are measured using isometric force transducers.
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With different types of mounts, tissue such as aortic rings, trachea, veins, uterine, colon, ileum, diaphragm (and many more) are submerged in a >8 ml chamber and kept in a headed perfusate. One end is attached to a force transducer and the other end to a micrometer. The micrometer enables the accurate setting of pre-load while sensitive force transducers provide the isometric measurement of vessel or muscle contractions.
Following mounting and equilibration, the length-tension relationships of the tissue can be determined. During the experiment, the length of the muscle is kept constant, and compounds can be added directly to the chamber to assess function.
There is no longer a need to physically change transducers as the 820MO is equipped with selectable force ranges on the transducer. Simply select the range that gives the most sensitive data collection for various tissue types. The rectangular chamber shape is made of acid-resistant stainless steel, which prevents lipids from sticking to the surface.