Dec provide custom designed isolators for dispensing and/or sampling from various containers such as bags and drums into intermediate packagings or for direct charging into process equipment. These systems offer high containment and a controlled environment offering fast cleaning and drying features allowing for swift product changes. Depending on the type of incoming packaging, the systems can be equipped with an airlock, a Rapid Transfer Port (RTP) or a drum docking system for material entry. Dispensing and/or sampling isolators can be equipped with multi-scale systems including data acquisition and possible connection to an MES system for recipes management.