Depending on the process, filter discharging isolators are generally designed as double-chamber glove box isolators, specifically conceived for use with an on-site filter dryer for toxic or sterile applications. The upper chamber serves for powder discharge, heel recovery and sampling from the filter dryer and the lower chamber is used for contained powder collection into bags or drums. Other equipment such as conical mills, etc. can be easily integrated. CIP wash gun assemblies and rotating spray heads generally provide easy cleaning. The system allows to discharge powder under containment from small filter dryers to large production scale dryers of a few sqm.