The Pharma 40DC industrial vacuum cleaner is a compact, quiet and flexible unit designed for dust containment during operations with highly powerful HPAPI active ingredients. The construction, designed to provide maximum dust filtration and total operator safety, fully complies with GMP guidelines and all maintenance operations are carried out by using systems that guarantee maximum safety, making it suitable for work with pharmaceutical powders and guaranteeing maximum containment levels up to OEB5 (during production) and OEB4 (during maintenance). The polished AISI316 stainless steel cyclone separates 98% (maximum, tested with placebo dust) of the extracted dust without the use of a filter unit and with no maintenance required. The Wash in place optional is available for the internal cleaning of the unit. The remaining dust is retained by a HEPA absolute filter that can filter dust up to 0.18 microns with an efficiency of 99.995% (with the possibility of installing 2 more, one on the intake and one on the air outlet) and a Bibo (BagIn-BagOut) system, which allows the absolute filter to be replaced without coming into contact with the sucked-in dust. A capacitive level probe signals when the container is full.