Buffer solution reagent SPR-476B

for researchdiagnosticclinical

Active Human Tau Deletion Protein Monomer is intended for research use only and not for use in diagnostic or clinical procedures. Active Human Recombinant Tau (K18) K280 Deletion Protein Monomer The Active Human Tau Deletion Protein Monomer is For Research Use Only Specificity: N/A Species: Human Expression System: E. coli Buffer: PBS pH 7.4 Alternative Names: Active tau monomer, active tau protein monomer, active tau protein, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Monomer, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, 95-amino acid tau protein fragment, Truncated Tau Protein, MAPT DeltaK280, K280 deletion tau, K18 delta K280 tau, truncated delta K280 tau Scientific Background Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). The delta K280 mutation is associated with frontotemporal dementia and promotes fibrillization into paired helical filaments (PHFs) in the absence of heparin and other inducers (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5).