Buffer solution reagent SPR-477B

for researchliquidprotein

Active Human Recombinant Tau (K18) K280 Deletion Protein Pre-formed Fibrils are intended for research use only and not for use in diagnostic or clinical procedures. The Active Human Recombinant Tau (K18) K280 Deletion Protein Pre-formed Fibrils are For Research Use Only Specificity: N/A Species: Human Expression System: E. coli Buffer: PBS pH 7.4 Alternative Names: Active tau PFFs, active tau protein preformed fibrils, active tau aggregates, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, MAPT DeltaK280, K280 deletion tau, K18 delta K280 tau, truncated delta K280 tau Product manufactured in Canada by StressMarq. Scientific Background Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). The K280 deletion mutation is associated with frontotemporal dementia and promotes fibrillization into paired helical