Buffer solution reagent SPR-484B

for researchpathologyliquid

The Human Recombinant Alpha-Synuclein Oligomers (Kinetically Stable) are for research use only and not to be used for diagnostic procedures. Human Recombinant Alpha Synuclein Oligomers (Kinetically Stable) The Human Recombinant Alpha Synuclein Oligomers (Kinetically Stable) Are For Research Use Only Specificity: N/A Expression System: E. coli Buffer: PB pH 7.4 Alternative Names: Alpha synuclein protein, Alpha-synuclein oligomer, Alpha synuclein protein oligomer, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, Alpha synuclein oligomers, Alpha Synuclein Protein Oligomers, SYN protein, Parkinson’s disease familial 1 Protein Product manufactured in Canada by StressMarq. Scientific Background Our kinetically stable oligomers of alpha-synuclein are generated without an inducer or inhibitor and remain stable for at least 2 weeks at 37oC. They present as globular structures under TEM, demonstrate toxicity in rat primary dopaminergic neurons, and induce Parkinson’s-associated alpha-synuclein phosphoserine 129 pathology. These oligomers have been previously characterized as globular, cylindrical structures with a betasheet structure intermediate between monomers and fibrils, and were demonstrated to have a higher toxicity to neurons than alpha-synuclein fibrils (1,2). Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (3). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum, and thalamus (4)