Rapid antimicrobial susceptibility test Polymyxin™ NP

for antigensglucoseenterobacteriaceae

The Rapid Polymyxin NP test has been designed for the detection of Enterobacteriaceae susceptibility and resistance to polymyxins (Colistin, and polymyxin B) from colonies grown on agar plates or directly from positive blood cultures. Reliable approach, regardless of the molecular mechanism of resistance (MCR1 and others) Easy to perform, highly specific and sensitive Excellent correlation with the reference broth microdilution method in 24h Benefits Among the most clinically significant multidrug-resistant bacteria are carbapenemase-producing Enterobacteriaceae. Because these bacteria usually remain susceptible to polymyxins, interest in this old class of antibiotics has been recently renewed. However, the increasing use of colistin explains why Enterobacterial strains resistant to colistin are increasingly reported worldwide. Currently available polymyxins susceptibility methods are fastidious, time-consuming (24 hours) and some methods are not reliable. They are poorly adapted to the clinical need and to the prevention of the dissemination of those multidrug resistant isolates. ELITechGroup Microbiology proposes a reliable Rapid Polymyxin NP test to detect polymyxins (polymyxin E or Colistin, polymyxin B) resistant Enterobacteriaceae. This test is based on the detection of the glucose metabolization related to bacterial growth in presence of a defined concentration of colistin. Formation of acid metabolites consecutive to the glucose metabolization is evidenced by a color change (orange to yellow) of a pH indicator. The Rapid Polymyxin NP test is easy-to-perform, very sensitive and specific.