The isolated heart perfusion system is a versatile solution to investigate small mammalian heart function, in health and disease, or following drug challenges.
Using either the Langendorff or the Working Heart technique, it allows the simultaneous assessment of cardiac electrophysiological and mechanical parameters (ECG, LVP, perfusion flow & pressure, etc.).
The isolated heart perfusion system provides highly reproducible experimental conditions to ensure survival of the isolated heart during several hours.
Typical Langendorff & Working Heart Applications
Safety Pharmacology
Toxicology
Heart failure & Cardiac Model development
Arrhythmia
Vascular biology
Cardiotoxicity
Cardiomyopathy