IgM assay kit Is EBNA-1

IgGfor Epstein-Barr virusclinical

Is EBNA-1 IgM ELISA test is designed for qualitative determination of IgM antibodies to Epstein-Barr Virus (recombinant) Nuclear Antigen-1 (EBNA-1 IgM) in human serum. Clinical Significance: Epstein-Barr virus (EBV) is a member of the herpesvirus family that infects human lymphocytes. It is known to cause infectious mononucleosis (IM) and is transmitted primarily by saliva. As with other herpesviruses, EBV causes a persistent latent infection with intermittent reactivations. EBV infection is usually asymptomatic in infants and young children. In adolescents and young adults infection usually results in IM. Humoral response to primary EVC infection appears to be quite rapid. Antibodies to EBV are made to various viral proteins, with specific antibodies correlating to disease state. In acute infection, IgM and then IgG antibodies are sequentially made to EA-D, VCA and EBNA. Current or recent infection is marked by the presence of IgM antibodies to VCA, EA and EBNA. IgG antibodies to VCA and EA are normally present in current infection, while IgG antibodies to EBNA are absent. Post-EBV infection is indicated by sustaining IgG antibody to VCA and EBNA and the absence of IgM antibodies. Thus, the monitoring of EBV antibody patterns may assist in the diagnosis of EBV infection since individual levels of specific antibodies may not necessarily be indicative of disease but can be of diagnostic importance when monitored as a profile. Technical Specification Test Qualitative Measuring range Cut-off Index value 1.1 Wavelength - 450 nm/ 600 - 630 nm