Control testing system HPLC On-/Offline System

temperaturedissolutionsignal

The ERWEKA Dissolution HPLC On-/Offline System is the semi-automatic solution for 100% USP/EP/JP compliant dissolution testing with HPLC online analysis. Up to 5 of 8 dissolution steps can be automated by combining one of our highly qualified DT 950 series dissolution testers with devices for CTC sampling and online HPLC chromatography. The entire system is controlled by our Disso.NET software. For filtrations up to 0.22 µm, our automated filter changer AFC 825 can be used in combination with our maintenance-free PVP pump. In addition, to a precise and simple control of the entire system, Disso.NET offers an accurate recording of the whole test process, from the automatic recording of the sampling time up to the recording of the temperature and rotation speed in each vessel (= Documentation of all system operations, audit trail). The dissolution tester of the DT 950 series is 100% compliant to USP methods 1, 2, 5 and 6 and can be operated in high-head as well as low-head mode. After dissolution testing* with the DT 950 and double filtration with the PVP 820 pump and the AFC 825, the medium is transferred to the HPLC sampler. There, the medium is first filled in a transfer block (PEEK block), and afterwards distributed into appropriate vials. If required, the samples can be diluted for immediate analysis or cooled and stored temporarily against UV radiation for later analysis. The HPLC analysis starts as soon as a sample is filled into the HPLC valve of the sampler and a trigger signal is sent by the Disso.NET to the HPLC device. The analysis as well as the evaluation are done by the analysis software of the corresponding HPLC manufacturer on a separate PC.