2’O-Me RNA are partially resistant to a variety of ribo- and deoxyribonucleases. They form more stable hybrids with complementary RNA strands than equivalent DNA/RNA sequences. They are ideal for antisense probes.
Phosphorothioate bonds possess an increased resistance against nucleases due to the substitution of a non-bridging oxygen by sulphur.
Length: From 5 to 139 bases
Synthesis scale: 10 nmol - 40 nmol - 200 nmol - 1000nmol - 2.5 µmol - 5µmol - 10 µmol (Larger quantities available on request)
Modifications: More than 300 modifications available
Purifications: SePOP desalting, HPLC, PAGE, Dual HPLC, UltraPureGold™
Quality Control: MALDI-TOF MS
Format: Dried. other formats on option
Packaging: 2 mL tube, 96-well or 384-well plates. Higher scales from 2.5 µmol may be delivered in 50mL tubes.
Specifications
Chemistry
Linkage -
Phosphorothioate Linkage
Modification
Modification Position -
3'
5'
IN
Storage & stability
Resuspension condition -
- Spin the tube briefly to collect the pellet in the bottom of the tube - Add an appropriate volume of recommended buffer (refer to technical data sheet) - Allow the tube to stand a few minutes - Vortex the tube for 15 seconds
Storage Conditions -
Dried Oligonucleotides are stable for 18 months at ambiant temperature. Oligonucleotides in solutions are stable for 24 months at -20°C. (Tolerance -20°C± 5°C. ) For more information please refer to the Reconstitution-Storage-Stability page