Heart failure test kit

NGALplasmaELISA

Firalis NGAL ELISA kit is intended to be used for the in vitro quantification of human NGAL in human EDTA plasma samples as an aid to diagnose HFrEF in patients with history of acute myocardial infraction. NGAL, a protein belonging to lipocalin family, is one of the earliest troponin like marker of acute kidney injury. It has emerged as the promising predictive biomarker for the clinical outcomes such as dialysis requirement, mortality in cardiac surgery, critical care and contract nephropathy. Besides kidney, NGAL also plays an important role in vascular remodeling and plaque instability of atherosclerosis. NGAL is found to beupregulated in cardiomyocytes in failing myocardium. Plasma NGAL is a significant predictor of mortality and cardiovascular disease in community-dwelling older adults, independent of traditional risk factors and kidney function, and adds incremental value to NT-proBNP and CRP9. All these findings suggest the potential role of NGAL as a biomarker in cardiovascular diseases. In an atherosclerosis model of heart disease, NGAL mRNA expression was upregulated as compared to control mice. In a rat model of acute heart failure (AHF), NGAL was upregulated in the cardiomyocytes of non-ischemic left ventricular wall. NGAL was also strongly expressed in cardiomyocytes of a rat model of autoimmune myocardities. NGAL was highly induced in the intima after balloon injury to the common carotid artery in rats12. Finally MRI images of abdominal aorta from ApoE2/2/eNOS 2/2 mice who were injected with NGAL/24p3-targeted micelles showed enhancement of MRI. This was confirmed by histology and co-localization of micelles & macrophages.