The thick-walled, durable media bottles provide ideal gas barrier properties, eliminating expensive process of cleaning, pyrogenicity, and dry heat sterilization, and are certified aseptic and pyrogen-free. Suitable for long-term and low temperature (−40°C) storage, can be used for sampling active pharmaceutical ingredients and intermediates storage. It is also suitable for preparing and sealing buffers, culture fluid or storing ph-sensitive liquids such as culture media, blood serum, etc.