PlaSon of Grand Aespio is developed based on the atmospheric pressure plasma and ultrasonic technology. The system can be used in combination as well as in separate function of PlasmaPoration™ and SonoPoration™, or can be used in combination of both. It is effectively used in transdermal drug absorption, wrinkles, scar, peels, inflammation and wound healing. By opening up the skin with PlasmaPoration and driving drug absorption with SonoPoration, it is an ultimate TDDS that one can ever dream of.