Microalbuminuria (MAU) Rapid Test Kit (Colloidal Gold) is intended for qualitative determination of albuminuria levels in urine in vitro diagnostic. It is used as a supplementary method in the diagnosis of chronic kidney injury(CKI).
【Background】
Microalbuminuria(MAU) is a term to describe a moderate increase in the level of urine albumin. It is also named urine microalbuminuria(UMA or mALB) Albumin is a normal protein in the blood, But under physiological condition sit appear only very small amounts of albumin in the urine. Albumin molecular weight is 70KD, isoelectric point (IEP)is about 4.85.MAU occurs when the kidney leaks small amounts of albumin into the urine, So increased excretion of albumin (microalbuminuria) is an early indicator of glomerular disease.
The researches have showed that MAU can be caused by diabetic nephropathy, hypertension, and cardiac insufficiency.
【Principle】
MAU Rapid Test Kit utilizes colloidal gold labeling and immune chromatography based on the principle of competitive binding to detect of albumin in human urine. During testing, a urine specimen migrates upward by capillary action. Albumin, if present in the urine specimen at an insufficient concentration, will not saturate the binding sites of antibody coated particles in the test strip. The antibody coated particles will then be captured by immobilized albumin conjugate and a visible colored line will show up in the test line region. The colored line will not form in the test line region if the albumin concentration is sufficient because it will saturate all the binding sites of anti- Albumin antibodies.