Cardiology organ perfusion system IH-SR

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The IH-SR Langendorff Core System is the starting point for all isolated perfused heart experiments on small rodents such as mouse, rat and guinea pig in the Langendorff retrograde perfusion mode. The Core System contains all the primary equipment you need to accomplish the basic Langendorff experiment. A fully functional IH-SR Langendorff System additionally requires the selection of core system options and other components including: Method of constant pressure perfusion Species-specific additions (cannulae, buffer reservoirs and balloons) Desired data acquisition system The IH-SR Langendorff Core System can be upgraded to a fully ejecting working heart system (according to Neely), accommodating aortic flows up to 60 ml/min. Other options enable additional measurement and application-specific capabilities. Advanced System Design Advanced design provides ease-of-use and exceptional stability of measurements while maintaining the flexibility to upgrade to more advanced capabilities. IH series systems do not use high water-columns to achieve a constant pressure and rely on instead other safer methods (Starling resistor or feedback-based perfusion controller) that keep every portion of your system within easy reach. The aortic block is fully enclosed in the water-jacketed upper and lower IH-SR heart chamber and precision milled from thermally stable Perspex. This design allows for precise temperature control and stability, making it the optimal choice for mouse heart perfusion. Because of its larger heart chamber, this system is well-suited for applications that require ECG and MAP recordings in addition to LVP and pacing.