Sepsis test kit HUBI DUO

for cardiovascular diseasescardiac troponin Icalcium

HUBI Cardiac DUO is one step in vitro diagnostic test based on immunochromatography. It must be used with HUBI QUAN pro and designed for quantitative détermination of CK-MB, Cardiac Troponin I in human whole blood, plasma or serum. The Troponin complex is located on the myosin filament of the actomyosin contractile apparatus of muscle. Troponin complex consist of Troponin T, which binds the Troponin complex to the tropomyosin strand, Troponin C, which binds calcium and regulates contraction, Troponin I, which inhibits myosin ATPase activity. There is one cardiac specific isoform of cTnl, with a molecular weight of 26.5kDa. cTnl becomes elevated 4~9 hours following an acute myocardial infarction (AMI) and remains elevated for about 6-10 days. Concentrations can increase 10~1000 times the upper limit of values found in normal healthy subjects. Smaller increases may be found in patients presenting with unstable angina, sepsis, pericarditis, injury due to trauma etc. TnT is a 39kDa protein. There are a number of cardiac isomers of TnT which have 40~45% dissimilarity with skeletal muscle TnT. 6~8% of cardiac TnT (cTnT) is found in the cytoplasm and the remainder is found complexed in tropomyosin. cTnT becomes elevated 4~9 hours following an acute myocardial infarction (AMI) and remains elevated for about 8 days. Levels may increase more than 100 times the upper limit of values found in normal healthy subjects. Smaller increases may be found in patients presenting with unstable angina. Creatine Kinase MB(CK-MB)is an 82,000 Dalton cytosolic enzyme that is present in high concentrations in the myocardium.