Coagulation test strip microINR

INRbloodcapillary blood

The microINR Chip is a disposable plastic test strip, that encloses two microcapillary channels, of extremely simple construction and fully passive (i.e. no built-in sensors, nor electrodes, nor external pumping). Microfluidics Chips The INR determination is achieved through sample flow monitoring along the microcapillary channels of the Chip, following the activation of the coagulation cascade. The current IVD test mimics the conditions of “in vivo” hemostasis, also referred as “ex vivo” Entry Channel The blood sample introduction is performed through the entry channel, where the sample flows by capillary action Reaction Chambers After blood sample application on the Chip, the coagulation cascade is activated by a microdispensed amount of recombinant thromboplastin reagent Microcapillary channels INR determination is performed through capillary blood flow monitoring along microfluidic channels. Control Channel Parallel control channel to check reagent integrity Measurement Channel When clotting, blood undergoes a change on the behavior and, thus, a sudden flow rate decay, which is detected by an embedded Machine Vision System (MVS) Datamatrix The measured prothrombin time is converted into INR using lot-specific calibration parameters microprinted on the Chip surface (Datamatrix) Chip Safety and reliability On-board quality control Chips individually packed Solid strip Chip Specifications High sensitivity human recombinant thromboplastin Real control assay in parallel channel Chip expiry and calibration parameters coded and integrated into the Chip Individually packed Storage at room temperature (2-25ºC / 36-77ºF) 15 Months shelf life