Solution reagent kit A-R0200001401

blood samplefor clinical chemistryliquid

Product for use in the quantitative determination in vitro of the concentration of LDL cholesterol in human serum or plasma. The results of the test must always be interpreted in conjunction with the clinical context. For professional use only. CLINICAL SIGNIFICANCE Total cholesterol in humans is principally distributed between three major classes of lipoproteins: VLDL (very low-density lipoproteins), LDL (low density lipoproteins) and HDL (high density lipoproteins). An increase in the plasma levels of LDL cholesterol constitutes one of the major risk factors for the development of coronary heart disease (CHD). In humans, LDL are carriers which transport two thirds of the blood cholesterol, having an important role in the formation of aterosclerotic plaques. LDL catabolism takes place in the liver and peripheral tissues following interaction with specific highaffinity LDL receptors. The presence of these receptors has been demonstrated in most cells, although they are more numerous in certain types, e.g. adrenocortical cells in which LDL cholesterol acts as principle substrate for the synthesis of steroid hormones. A defect in the process of removal of LDL or the superposition of low-density lipoproteins, precursors of LDL, can cause an increased concentration of LDL in the serum. The precipitation method for the determination of LDL cholesterol is little used because the results are often inaccurate in the presence of high serum triglycerides levels.