Epidemiology
Cervical cancer is one of the most common types of female cancer worldwide, and its occurrence is closely related to human papillomaviruses (HPV), but only a small proportion of HPV infections can develop into cancer. High-risk HPV infects cervical epithelial cells and produces two oncoproteins, E6 and E7. This protein can affect a variety of cellular proteins (such as the tumor suppressor proteins pRB and p53), prolong the cell cycle, affect DNA synthesis and genome stability, and interfere with antiviral and antitumor immune responses.
Channel
Channel - Component - Genotype tested
FAM - HPV Reaction Buffer 1 - HPV16、31、33、35、51、52、58
VIC/HEX - Human β-actin gene
FAM - HPV Reaction Buffer 2 - HPV 18、39、45、53、56、59、66、68
VIC/HEX - Human INS gene
Technical Parameters
Storage - Liquid: ≤-18℃
Shelf-life - 9 months
Specimen Type - cervical exfoliated cell