Intended Use
This kit is used for the qualitative detection of carbapenem resistance genes in human sputum samples, rectal swab samples or pure colonies, including KPC (Klebsiella pneumonia carbapenemase), NDM (New Delhi metallo-β-lactamase 1), OXA48 (oxacillinase 48), OXA23 (oxacillinase 23), VIM (Verona Imipenemase), and IMP (Imipenemase).
Epidemiology
Carbapenem antibiotics are atypical β-lactam antibiotics with the broadest antibacterial spectrum and strongest antibacterial activity. Because of its stability to β-lactamase and low toxicity, it has become one of the most important antibacterial drugs for the treatment of severe bacterial infections. Carbapenems are highly stable to plasmid-mediated extended-spectrum β-lactamases (ESBLs), chromosomes, and plasmid-mediated cephalosporinases (AmpC enzymes).
Channel
Channel Name - PCR-Mix 1 - PCR-Mix 2
FAM Channel - IMP - VIM
VIC/HEX Channel - Internal Control - Internal Control
CY5 Channel - NDM - KPC
ROX Channel - OXA48 - OXA23
Technical Parameters
Storage - ≤-18℃
Shelf-life - 12 months
Specimen Type - Sputum, pure colonies, rectal swab