Genetic mutation test kit

for EGFR mutationsbloodplasma

EGFR (Epidermal Growth Factor Receptor), belongs to the proto-oncogene, On the short arm of human chromosome 7, containing 28 exons. EGFR mutations associated with TKI drug reactivity are concentrated in exon 18-21. There are 29 common mutation types, Exon 19 deletion mutation and exon 21 L858R point mutation rate was the highest. About 45% of the 747-750 amino acids were missing from exon 19, delE746-A of which 750(2235-2249 del and 2236-2250 del) are most common. About 40-45% of 858 amino acid substitution mutations on exon 21; exon 18-point mutations (G719S or G719C) account for about 5%; Insertion mutations on exon 20 accounted for about 1% of the total. And some mutations are associated with TKI resistance, mutations T790M exon 20 result in TKI resistance in about 50% of patients. [intended use] iThis kit is used for qualitative detection of paraffin-embedded pathological tissue or sections, fresh tumor tissue in patients with malignant non-small cell lung cancer (NSCLC) in vitro and 29 mutations in exon 19, exon 21, exon 18, and exon 20 of the epidermal growth factor receptor (EGFR) gene in peripheral venous plasma. The first CFDA approved kit for blood EGFR testing, Ultra-ARMS technology, Can detect EGFR( epidermal growth factor receptor) gene mutation, Product specificity, sensitivity, A total of 29 mutation sites including drug sensitivity and drug resistance were covered.