7 Kinds of Mutation in K-Ras Gene Test Kit
Prevention of Lung Cancer or Colorectal Cancer
This kit is intended for the qualitative detection of 7 common mutations in codons 12 and 13 of the K-ras in DNA extracts of tumor tissue samples from patients with lung cancer or colorectal cancer fixed in formalin and paraffin-embedded, and can identify the types of mutations.
K-ras oncogene is located on human chromosome 12 and plays an important role in the development of human tumors. K-ras acts as a molecular switch: it controls the pathways that regulate cell growth under normal conditions; when abnormalities such as mutations occur, the gene is permanently activated, causing intracellular signal transduction disorders, leading to continuous cell growth and preventing cells apoptosis, and thus leads to cancer. Mutations in the K-ras gene occur in the early stages of tumorigenesis, and the K-ras genes of the primary and metastatic lesions are highly consistent.