Automatic sample preparation system EM ICE

laboratoryfor researchcooling

High pressure freezing is key for the study of intricate changes in fine structure or cellular dynamics. - Cryo-immobilize your aqueous samples under high pressure with a unique freezing principle and uncover secrets of the cellular process. - Capture and resolve highly dynamic processes at the nanometer scale with millisecond precision. The EM ICE solution, combining superior high pressure freezing with the possibility of light and electrical stimulation, is the platform for your discoveries. Currently cryo-fixation is the only way to fix cellular constituents without introducing significant structural alterations. The EM ICE solution uses a unique, alcohol-free freezing principle to allow a superior cryo-fixation of the specimen enabling better quality results to be obtained: - No alcohol in the chamber leads to a faster pressure increase and immediate cooling of the specimen - No alcohol residue on the carrier or the specimen - Precisely define the timing for light and electrical stimulation. Why Electrical Stimulation? To resolve controversial questions in neurobiology, it is essential to employ new techniques for visualizing cellular activity. The EM ICE solution offers electrical stimulation of neurons with millisecond precision and complete coordination of electrical discharge at the moment of freezing. It gives neurobiologists the most reliable tool for capturing and imaging action potential and membrane trafficking events. Why light stimulation? Synchronizing light stimulation and high pressure freezing enables you to visualize in photosensitive specimens: highly dynamic processes and structural changes