Implantable neurostimulator AspireSR™

for vagus nerve stimulation

AspireSR™ detects and responds to rapid increases in heart rate, which may be associated with a seizure In clinical trials, over 60% of seizures treated ended during automatic stimulation. The closer the stimulation to seizure onset, the shorter the seizure duration VNS Therapy™ controls seizures in 3 ways Normal Mode Helps Prevent seizures Stimulation is delivered at regular intervals all day, every day, to help prevent seizures AutoStim Mode Responds to rapid increases in heart rate An extra dose of therapy is automatically delivered at the sign of a rapid increase in heart rate, which may be associated with seizures Magnet Mode Delivers On-Demand Treatment Stimulation is manually delivered by swiping the included VNS Therapy™ magnet over the generator to help stop or shorten a seizure once it starts VNS Therapy™ Can De-Intensify Seizures and Provide Improvements in Seizure Control 59% reported ≥ 50% reduction in seizures 41% reported ≥ 80% reduction in seizures * Data is from devices with AutoStim Mode enabled, which is only available in models 106, 1000, and 1000-D. VNS Therapy™ can reduce the impact of seizures and can help improve post-ictal recovery Clinically meaningful improvement from baseline AspireSR™ is shown to improve quality of life Clinically meaningful and statistically significant improvements in overall QOL were seen at 3 months and continued to improve over time. AspireSR™ - Advancing the treatment of drug-resistant epilepsy Provides demonstrated efficacy and safety of VNS Therapy May terminate seizures by delivering automatic stimulation when a seizure occurs