During the early years of the pharmaceutical industry, liquid products such as medicines were stored in small ampoules. Today, modern glass ampoules are used to store sterile solutions. These ampoules are made from short lengths of glass tubing.
During the mid-1890s, a French pharmacist named Stanislaus Limousin invented a new form of glass ampoulle. This new type was designed to safely store sterile solutions and liquids.
The modern-day ampoules are filled with a variety of specialized machines. These include machines that draw powders into the bottles, and those that seal the ampoules. The ampoules are then sterilized in autoclaves. They are then purged with nitrogen gas, which removes the atmospheric air from the bottles.
Many manufacturers of these types of machines are now launching models to increase production efficiency. These machines utilize several technologies, such as programmable logic controllers, to improve aseptic conditions. They also clean and label the bottles.
A typical filling machine includes a slant hopper and a pre-warming station. The slant hopper can hold up to eight ampoules at a time. The machine is then equipped with a sealing station, a combustible gas supply, and pressure reducers. It is covered with a stainless steel matt finish. The sealed ampoules are then automatically collected on a collection tray.
The liquid-filled ampoules are generally sealed using a tip-sealing method. This is the most common technique. It involves uniform heating of the neck of the ampoule. This causes the glass to soften and a bead to form.