NfL reagent MF-NFL-0060

antibodyclinicalliquid

-Quantify NfL in the sample easily, rapidly, and accurately -Magnetic Nanoparticle -Dextran layer -For Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington disease (HD) and for in-vitro diagnosis use Description Intended Use “MagQu” Neurofilament light IMR Reagent is used to quantitatively measure neurofilament light(NfL) in human fluid specimen, such as plasma, serum or CSF. Use “MagQu” Neurofilament light IMR Reagent only with the XacPro-S System (MagQu Co., Ltd.). Introduction Neurofilament light(NfL) is a specific cytoskeletal protein highly expressed in largely myelinated axons. Increased levels of NfL in CSF and blood are clinically useful biomarkers in many neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington disease (HD). 1,2 Principle of Test “MagQu” Neurofilament light IMR Reagent is designed for rapid quantifying NfL by ImmunoMagnetic Reduction (IMR). We conjugate antibody on the surface of around 50 nm-in-diameter Fe3O4 magnetic particles. When the antibodies on the surface bind with NfL, the magnetic particles form clusters. Therefore, the ac susceptibility (Xac) of magnetic particles would be reduced in the adding ac magnetic field. By measuring the reduction of Xac, NfL can be easily, rapidly and accurately quantified. Specification: Core Iron Oxide (Fe3O4) Layer Dextran Surface protein Anti-Neurofilament light antibody Mean Diameter of Particles 50 ~ 60 nm The analytical range of reagent 0.01 to 100 pg/mL neurofilament light protein Buffer pH 7.4 PBS