TDP-43 reagent MF-TDP-0060

antibodyclinicalliquid

-Magnetic Nanoparticle -Dextran layer -For ALS, FTLD and Alzheimer’s disease Description Intended Use “MagQu” TDP-43 IMR Reagent is used to quantitatively measure TDP-43 protein in human fluid specimen, such as plasma, serum or CSF. Use “MagQu” TDP-43 IMR Reagent only with the XacPro-S System (MagQu Co., Ltd.). Introduction The TAR DNA binding protein of 43 kDa (TDP-43) is a ubiquitously expressed nuclear protein with roles in transcription and splicing regulation. A hyper-phosphorylated, ubiquitinated and cleaved form of TDP-43, known as pathologic TDP-43 is the major disease protein in ubiquitin-positive, tau and α-synuclein-negative frontotemporal dementia (FTLD-TDP, previously referred to as FTLD-U) and in amyotrophic lateral sclerosis (ALS). Evidences indicates that TDP-43 can be detected in human plasma and CSF and levels are reportedly elevated in cases of ALS, FTLD and Alzheimer’s disease. 1,2 Principle of Test “MagQu” TDP-43 IMR Reagent is designed for rapid quantifying TDP-43 by ImmunoMagnetic Reduction (IMR). We conjugate antibody on the surface of around 50 nm-in-diameter Fe3O4 magnetic particles. When the antibodies on the surface bind with TDP-43, the magnetic particles form clusters. Therefore, the ac susceptibility (Xac) of magnetic particles would be reduced in the adding ac magnetic field. By measuring the reduction of Xac, TDP-43 can be easily, rapidly and accurately quantified. Specification: Core Iron Oxide (Fe3O4) Layer Dextran Surface protein Anti-TDP-43 antibody Mean Diameter of Particles 50 ~ 60 nm The analytical range of reagent 0.001 to 100 pg/mL TDP-43 protein Buffer pH 7.4 PBS